According to the Highway Patrol report, a 2017 Jeep Patriot driven by a 26-year-old Springfield woman ran off the left side of the roadway and overturned.
She was pronounced dead at the scene at 2:56 a.m.
A passenger, a 28-year-old Lebanon man, was treated for minor injuries at Cox South Hospital, Springfield.
The fatality was the 74th this year for Highway Patrol Troop D.